The purpose of this study was to develop and optimize formulations of mucoadhesive bilayered buccal patches of sumatriptan succinate using chitosan as the base matrix. Mucoadhesive system can be used for targeting the drug to a. Comparative efficacy of topical therapy with a slowrelease mucoadhesive buccal tablet containing miconazole nitrate versus systemic therapy with. Miconazole nitrate mn is a broadspectrum antifungal agent that has been extensively applied for the management of dermal, buccal and vaginal candidiasis. Miconazole nitrate is a common and safe topical treatment for fungal infections including athletes foot, jock itch and ringworm. Mucoadhesion is a term used for materials bind to the mucin layer of the. How to use loramyc 50 mg, tablet do not swallow loramyc instructions for proper use loramyc must be applied to the. Miconazole vs clotrimazole for ringworm answers on healthtap. Design and characterization of chitosancontaining mucoadhesive buccal patches of propranolol hydrochloride. In this study, mucoadhesive patches were prepared with tamarind gum and hpmc. Miconazole nitrate 2% cream antifungal miconazole nitrate cream if this spl contains inactivated ndcs listed by the fda initiated compliance action, they will be specified as such.
Formulation and in vitroin vivo evaluation of naproxen mucoadhesive buccal patches for local effect author links open overlay panel m. Buccal bioadhesive films were prepared using increasing values of the. Systemic administration of anticancer drugs is associated with a number of side effects. A novel buccovaginal controlled release drug delivery. Formulation and evaluation of mucoadhesive buccal films of.
Design and evaluation of miconazole nitrate buccal. Manufacture and characterization of mucoadhesive buccal. The beaker containing polymer and ethanol was kept aside for 5 min for swelling of the polymer. It typically comes in the form of miconazole nitrate in a 2% topical cream and is marketed under several brand names including lotrimin af as a spray for jock itch tinea cruris. Mucoadhesive chitosan buccal film for the topical delivery of miconazole nitrate could be a successful mean for the management of oral candidiasis. A stray cat that hangs out at our house has ringworm. Katabira, comparative efficacy of topical therapy with a slowrelease mucoadhesive buccal tablet containing miconazole nitrate versus systemic.
Miconazoleurea in a buccal film as a new trend for. Miconazole contains certain active ingredients like miconazole nitrate, polyethylene glycol and ethyl alcohol. This ed material has been downloaded from a licensed data provider and is not for distribution, except. For this reason, several buccal formulations like gels 4, 5, mucoadhesive tablets 68, patches, and buccal films 915 have been developed using polymers that allow the most direct contact with the.
Find patient medical information for miconazole nitrate topical on webmd. Formulation and evaluation of mucoadhesive oral gel. The patches were prepared by solvent casting method and characterized by folding endurance, patch thickness, drug content, surface ph ph. Does anyone know if its safe to use miconazole nitrate 2%.
Design of novel miconazole nitrate transdermal films based on. Miconazole is most commonly used as a topical solution, which is applied regularly. Several buccal drug delivery devices containing miconazole were developed such as chewing gum, oral gel, bioadhesive buccal tablets and buccal patches. Miconazole nitrate 2 % antifungal foot cream proven clinically effective in the treatment of athletes foot tinea pedis, jock itch tinea cruris, and ringworm tinea corporis. Mucoadhesive buccal patches containing propranolol hydrochloride were prepared. To stop ringworm, medications must have the necessary components to kill fungi. The patches were prepared by solvent casting method and characterized by folding endurance, patch thickness, drug content, surface ph ph subject category. Doctors give unbiased, trusted information on the use of trichophyton for ringworm tinea. Preparation and evaluation of buccal bioadhesive films containing clotrimazole. It is used for ring worm of the body, groin jock itch, and feet. Mucoadhesive patches containing 10 mg miconazole nitrate were evaluated. Van roey j, haxaire m, kamya m, lwanga i, katabira e. Miconazole nitrate mn is a broad spectrum antifungal agent preferred in the treatment of oral candidiasis.
Development and evaluation of mucoadhesive buccal patches. Pdf comparison of the efficacy and safety of miconazole 50mg. Miconazole is a treatment solution that is often applied in fungal infections including the ringworm or the yeast infection. The main aim in the present study was to develop a novel mucoadhesive buccovaginal tablet to ensure satisfactory miconazole level in both buccal. Similar to clotrimazole, over the counter generic brands are also available as substitute ringworm. Miconazole nitrate administered orally at doses of 80 mgkgday or higher to pregnant rats or rabbits crossed the placenta and resulted in embryo and fetotoxicity, including increased fetal resorptions. Invitro dissolution studies of bioadhesive, buccal tablets were done by using tablet. Different formulations of buccal mucoadhesive patches of miconazole nitrate were prepared, which contain polymers hpmc e 50, carbopol, ethyl cellulose, in various combinations. Therefore, it needs some targeted drug delivery system to deliver the drug which would ensure relief from side effects along with the direct delivery of drug to the site of action in a controlled manner.
The efficacy and safety of miconazole nitrate mucoadhesive tablets versus. Research article, report by journal of drug delivery. Research studies on in vitro and ex vivo yield of the miconazole nitrate from oral biomucoadhesive tablets. Prepared films were evaluated for weight, thickness, surface ph. Mucoadhesive buccal films of glibenclamide were prepared by solvent casting technique using different grades of hpmc with different ratios. Miconazole is used to treat skin infections such as athletes foot, jock itch, ringworm, and other fungal skin infections candidiasis. The patches were prepared with ionic polymers, sodium carboxymethyl cellulose scmc and chitosan, or nonionic polymers, polyvinyl alcohol pva, hydroxyethyl cellulose hec and hydroxypropylmethyl cellulose. The patches were prepared with ionic polymers, sodium carboxymethyl cellulose. Mechanical, mucoadhesive and biocompatibility behavior of.
Hpmc was weighed 200 mg accurately and dissolved in 2 ml of ethanol. I got miconazole nitrate 2% formulation what i was told to get. These ingredients help to cure ringworm infections within 14 days. Miconazole lauriad 50 mg, mucoadhesive buccal tablet package leaflet 3. Comparative efficacy of topical therapy with a slow release mucoadhesive buccal tablet containing miconazole nitrate versus systemic therapy with ketoconazole in. What conditions does miconazole nitrate 2 % topical cream.
Before applying the tablet, locate the area on the upper gum, above the front tooth. Pdf mucoadhesive buccal patches of miconazole nitrate. Yes it can be used and is effective fo vaginal yeast infection. Formulation and in vitroin vivo evaluation of naproxen. I described this place on her bum to the vet on the phone and she advised me to either use a miconazole cream or a athletes foot cream. Furthermore, the antifungal activity of the selected film was significantly p miconazole oral gel daktarin. In the present work, studies will be carried out on the design and evaluation of buccal tablets of prochlorperazine maleate in order to, overcome bioavailability related problems bypass the firstpass. Buccal films of enalapril maleate were prepared by solvent casting technique using film forming mucoadhesive polymers table 1. Development and evaluation of mucoadhesive patches of miconazole nitrate.
Mucoadhesive hydrogel film with 15% polyvinyl alcohol and 7 freezethaw cycles. Miconazole works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes. Miconazoleurea in a buccal film as a new trend for treatment of. Some of the most common include ketoconazole nizoral, clotrimazole mycelex, terbinafine lamisil and miconazole.
As such, many of the antifungal medications prescribed for ringworm are topical or applied directly on the skin. Comparison of the efficacy and safety of miconazole 50mg mucoadhesive buccal tablets with miconazole 500mg gel in the treatment of oropharyngeal candidiasis. The patches were prepared with ionic polymers, sodium carboxymethyl cellulose scmc and chitosan, or nonionic polymers, polyvinyl alcohol pva, hydroxyethyl cellulose hec and hydroxypropylmethyl cellulose hpmc. Miconazole mucoadhesive tablet for oropharyngeal candidiasis. Oravig is specifically indicated for the local treatment of oropharyngeal candidiasis in adults.
Buccal bioadhesive films were prepared using increasing values of the drug mic. Mucoadhesive bilayered patches for administration of. In the present study, mucoadhesive oral gels of mn were prepared with carbopol 934p in. Gelatin and polyvinyl pyrrolidone pvp k30 were incorporated into the patches, to improve the film properties of the patches. Development of polymer patch dosage form of lidocaine for buccal. How to use loramyc 50 mg, tablet do not swallow loramyc instructions for proper use loramyc must be applied to the upper gum, just above a front tooth.
Does anyone know if its safe to use miconazole nitrate 2% on a cat for a fungal infection, or should clotrimazole cream usp 1% be used. Miconazole reduces the red skin patches, itching, and peeling that occur with these. Preparation and evaluation of buccal bioadhesive films. Mucoadhesive patches containing 10mg miconazole nitrate were evaluated. She said that this would not hurt if it wasnt ringworm, but if it is it would help. The present study involves the formulation and evaluation of buccal tablets of v enlafaxine hydrochloride, an antidepressant drug to circumvent the first pass metabolism.